Do SARMs Have Side Effects?

Posted by Tyler Hall on

Are SARMs Without Side Effects? 

The age-old question we get most often, "Do SARMS have sides?"

Also known as Selective Androgen Receptor Modulators, SARMs are tissue-selective, anabolic agents designed with the intention of replicating the anabolic effects of steroids in muscle tissue and bone without the androgenic effects in other affected tissues.

SARMs have a distinct advantage in terms of tissue selectivity, androgen-receptor specificity, and lack of side effects that are otherwise commonly experienced with steroids.

Anabolic steroids can cause various adverse effects in the human body.

Side effects like hair loss on the scalp, acne, hair growth on the body, & infertility are among several others that can all occur with steroid use.

These side effects are even more pronounced in females because of their Estrogen dominance.

The therapeutic potential of SARMs is incredibly promising but not without their own concerns.

The SARMs Side Effect Camps

We know like anyone, SARMs are currently hyped. "Gurus" and "experts" alike are all taking advantage of it on social.

"Experts" fall into two camps:

One camp will tell you that SARMs don't have sides.

The second camp will tell you they do and you should just use steroids.

Aside from the noise, SARMs DO bind with a high affinity to the androgen receptor and they work effectively.

They are not side effect free though.


Side Effects Of SARMs In Clinical Trials

There are only a handful of SARMs going through pharmaceutical clinical trials.

As of now, we'll use our most popular and documented SARM as an example, MK-2866.

Ostarine Side Effects

Ostarine also is known as Enobosarm, GTx-024, and MK-2866 is the most well known and extensively studied selective androgen receptor modulator (SARM) right now.

It is categorized as a SARM because of its unique selectivity at the androgen receptor where it exhibits a significant amount of anabolic activity in the body relative to androgenic activity.

It is being researched to determine if it is a potential treatment for the management of muscle and bone wasting diseases.

Effect On Lipids (HDL/LDL)

Reductions in serum lipids (HDL and LDL) occurred in a dose-dependent manner with Ostarine usage, while another study only showed reductions of HDL levels (otherwise known as “good cholesterol”) [RR].

We know for sure that Ostarine has a negative effect on HDL levels, which is notable as this is a common side effect of all traditional anabolic steroids and other SARMs. From an empirical standpoint, many of our rats have experienced not only a decrease in HDL but an INCREASE in LDL.

Natural Testosterone Suppression

Ostarine has also shown to significantly lower Sex Hormone-Binding Globulin (SHBG) and serum total testosterone levels in clinical trials in subjects treated with 1 mg of Ostarine or higher [R].

While SHBG was always significantly impacted at notable dosages, suppression of LH and FSH wasn't consistently proven.

We believe it's safe to say that Ostarine does also show blatant reductions in all of these hormones markers in a dose-dependent manner, the dosages in the studies just weren't high enough to yield this data. However, we have anecdotal evidence of our rats' bloodwork showing a decrease in both test serum levels and free test.

The degree to which even high dosages of Ostarine suppress LH and FSH is far less than that of traditional anabolic steroids.

The process of recovering to baseline healthy endocrine function would be hindered to a far greater extent in steroid users, AKA what happens after the cycle is complete and the experiment has now entered the post-cycle phase.

Liver Toxicity

The ALT observations in seven of eight subjects during a clinical trial had resolved while still continuing their daily dosage, and no subject had clinically significant abnormal levels of ALT or AST at the end of the study.

This was with dosages of no higher than 3mg per day. It's safe to assume that common recreational dosages of Osatarine (upwards of 25mg) may exhibit some level of liver enzyme elevation.

At therapeutic dosages, there appears to be a low-risk profile, but it should be noted that there may be some notable degree of liver toxicity at dosages commonly used for performance enhancement, which would likely resolve itself after cycling off. One can help mitigate these heightened enzymes by adding in some sort of liver support, like our NAC, in order to keep some stress off the liver.

Highest Dosage Of Ostarine Well Tolerated In Humans

Ostarine has been evaluated in 27 completed or ongoing clinical trials.

1500 subjects in total have been treated with Ostarine in some capacity, with dosages ranging from as low as 0.1mg all the way up to 100mg.

Ostarine was observed to be generally safe and well-tolerated in all of those trials.


Are SARMs Safer Than Steroids?

In a therapeutic context, when compared with steroidal androgens, SARMs appear to be much better tolerated with fewer incidences of severe adverse events.

They are also orally bioavailable, which lowers the risk of accidental exposure, which is a limitation of topical Testosterone.

Obviously, when it comes to the method of introduction, oral therapies are going to be favored over injections as well. One reason why we remain to stay in the liquid, oral availability sector.

When it comes to using massive dosages for non-therapeutic purposes, are SARMs still safer than steroids?


We believe certain SARMs are safer at all dosages, but the issue is that their muscle-building potential is lower than that of many anabolic steroids.

That answered your question right?

Yes. They're effective. Yes. They're safer.

The debate is not whether or not SARMs work, rather, their risk-for-reward profile is what is constantly in debate.

Wrapping this up, SARMs are not side-effect-free but they aren't as notorious as some "gurus" will claim.

There isn't enough data to make any conclusive statements on their long-term safety but from what we do know, we can see that their development is definitely on track to making a game-changing anabolic agent.

We're just happy to be alongside history being made.

Disclaimer: The information included in this article is intended for informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. We are not advocating the use of SARMs for recreational human use. Prior to buying anything, check that it is compliant where you live with your current government laws.